No abnormalities of thyroid function studies are known to occur. Rapid administration is to be avoided. Parenteral therapy is indicated only when oral therapy is not indicated. Oral therapy should be instituted as soon as possible. If intravenous therapy is given over prolonged periods of time, thrombophlebitis may result.
Studies to date have indicated that doxycycline at the usual recommended doses does not lead to excessive accumulation of the antibiotic in patients with renal impairment. Adults The usual dosage of intravenous doxycycline is mg on the first day of treatment administered in one or two infusions.
Subsequent daily dosage is to mg depending upon the severity of infection, with mg administered in one or two infusions. In the treatment of primary and secondary syphilis, the recommended dosage is mg daily for at least 10 days. In the treatment of inhalational anthrax post-exposure the recommended dose is mg of doxycycline, twice a day. Parenteral therapy is only indicated when oral therapy is not indicated and should not be continued over a prolonged period of time. Therapy must continue for a total of 60 days.
For children over pounds the usual adult dose should be used. General The duration of infusion may vary with the dose to mg per day , but is usually one to four hours. A recommended minimum infusion time for mg of a 0. Therapy should be continued for at least 24 to 48 hours after symptoms and fever have subsided. The therapeutic antibacterial serum activity will usually persist for 24 hours following recommended dosage.
Intravenous solutions should not be injected intramuscularly or subcutaneously. Caution should be taken to avoid the inadvertent introduction of the intravenous solution into the adjacent soft tissue. Each mg of doxycycline i.
Lactated Ringer's Injection 6. Concentrations lower than 0. Doxycycline in these solutions is stable under fluorescent light for 48 hours, but must be protected from direct sunlight during storage and infusion.
Reconstituted solutions 1 to 0. Doxycycline is indicated in the treatment of trachoma, although the infectious agent is not always eliminated, as judged by immunofluorescence. Contraindications This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines. This adverse reaction is more common during long-term use of the drugs but has been observed following repeated short-term courses. Enamel hypoplasia has also been reported.
Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including doxycycline for injection, USP, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C.
Hypertoxin producing strains of C. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracyclines.
Patients apt to be exposed to direct sunlight or ultraviolet light, should be advised that this reaction can occur with tetracycline drugs, and treatment should be discontinued at the first evidence of skin erythema. The anti-anabolic action of the tetracyclines may cause an increase in BUN. Studies to date indicate that this does not occur with the use of doxycycline in patients with impaired renal function.
Doxycycline for injection has not been studied in pregnant patients. It should not be used in pregnant women unless, in the judgment of the physician, it is essential for the welfare of the patient. Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues and can have toxic effects on the developing fetus often related to retardation of skeletal development.
Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. Usage in Children The use of doxycycline for injection in children under 8 years is not recommended because safe conditions for its use have not been established. As with other tetracyclines, doxycycline forms a stable calcium complex in any bone-forming tissue.
This reaction was shown to be reversible when the drug was discontinued. Tetracyclines are present in the milk of lactating women who are taking a drug in this class. Precautions Prescribing doxycycline in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. As with other antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi.
If superinfection occurs, the antibiotic should be discontinued and appropriate therapy instituted. In venereal diseases when coexistent syphilis is suspected, a dark field examination should be done before treatment is started and the blood serology repeated monthly for at least four months. Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
In long-term therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal and hepatic studies should be performed. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin. Pregnancy Category D There are no adequate and well-controlled studies on the use of doxycycline in pregnant women.
The vast majority of reported experience with doxycycline during human pregnancy is short-term, first trimester exposure. There are no human data available to assess the effects of long-term therapy of doxycycline in pregnant women such as that proposed for treatment of anthrax exposure. An expert review of published data on experiences with doxycycline us during pregnancy by TERIS-the Teratogen Information System-concluded that therapeutic doses during pregnancy are unlikely to pose a substantial teratogenic risk the quantity and quality of data were assessed as limited to fair , but the data are insufficient to state that there is no risk.
This association was not seen when the analysis was confined to maternal treatment during the period of organogenesis i. All mothers reported their exposed infants were normal at 1 year of age. Short-term use by lactating women is not necessarily contraindicated: Information for Patients Patients should be counseled that antibacterial drugs including doxycycline should only be used to treat bacterial infections. They do not treat viral infections e. When doxycycline is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed.
Skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by doxycycline or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued.
Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. Adverse Reactions Gastrointestinal Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis and inflammatory lesions with monilial overgrowth in the anogenital region.
De tabletten bij voorkeur tijdens of vlak na de maaltijd innemen. Men kan de tabletten op twee manieren innemen: Het is van belang alle voorgeschreven tabletten volgens schema in te nemen kuur afmaken. Wanneer u teveel van Doxycycline dispergeerbaar ratiopharm heeft ingenomen, neem dan onmiddellijk contact op met uw arts of apotheker. De volgende verschijnselen kunnen optreden bij een overdosering: Behandeling na inname bestaat uit laten drinken van water, braken opwekken, maagspoelen bij grote hoeveelheden en daarna 3 rvg PIL EV ren toediening van geactiveerde kool en laxeren door het geven van natriumsulfaat.
Neem geen dubbele dosis om een vergeten dosis in te halen. Wanneer u vergeten bent Doxycycline dispergeerbaar ratiopharm in te nemen, doe dit dan zo snel mogelijk alsnog.
Als het echter bijna tijd is voor de volgende dosering, sla dan de gemiste dosering over en ga verder met uw normale doseringsschema.
Raadpleeg bij twijfel altijd uw arts of apotheker. U dient de kuur af te maken. Overleg altijd met uw arts indien u overweegt te stoppen. Heeft u nog andere vragen over het gebruik van dit geneesmiddel? Neem dan contact op met uw arts of apotheker. Zoals elk geneesmiddel kan Doxycycline dispergeerbaar bijwerkingen hebben, al krijgt niet iedereen daarmee te maken. De volgende bijwerkingen kunnen onder andere optreden: Men kan de eerste twee verschijnselen veelal voorkomen door doxycycline tijdens de maaltijd in te nemen.
Minder vaak zijn gemeld gebrek aan eetlust, ontsteking van de tong, zwarte tong, slikstoornis en ontsteking van het slijmvlies van de dikke darm. Ook kan een schimmelinfectie ontstaan met diarree, ontsteking van de tong, mondslijmvlies, endeldarm en vagina Huidverschijnselen huiduitslag en overgevoeligheid voor zonlicht en ultraviolet licht overgevoeligheidsreacties o. Deze verschijnselen verdwijnen vanzelf binnen enkele dagen of weken na het staken van de behandeling.
Hoe bewaart u dit middel? Buiten het bereik en zicht van kinderen houden.
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